Trimethylamine N-Oxide: The Good, the Bad and the Unknown
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism.It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea.Plasma level of TMAO is determined by a number of factors including diet, gut m